6.3 Properties of Apovitellenin I (egg yolk)

6.3.1 Molecular Biological Properties
 

Apovitellenin I	References
Allergen Nomenclature none
Molecular Mass  9 kDa, tetramer 36 kDa (1)	(1) Burley & Davies 1976
Isoelectric Point pI
Amino Acid Sequence,mRNA, and cDNA Protein Apovitellenin I SWISS-PROT: P02659 PIR: VLCH1, I50374 GenBank: J00810, J00809, M14120 Amino Acids 82 aa (1, 2) mRNA precursor 2918 bp (4) cDNA precursor 4961 bp (3)	(1) Dopheide & Inglis 1976 (2) Jackson et al. 1977 (3) Dugaiczyk et al. 1981 (4) van het Schip et al. 1983
Posttranslational Modifications Disulfide bonds formation of homodimer by interchain disulfide bond: aa 75-75 (1)	(1) SWISS-PROT
Biological Function component of very low density lipoprotein (VLDL) of egg-laying females, lipoprotein lipase inhibitor (1)	(1) SWISS-PROT

 6.3.2 Allergenic Properties
 

Apovitellenin I	References
Frequency of Sensitization IgE-binding to apovitellenin I in 100% of patients with egg yolk allergy (1)	(1) see 6.1 Sensitization to Allergens of Bird's Egg Yolk and Feathers