Allergen Data Collection - Update: Bird-Egg Syndrome (Egg Yolk, Feathers)
Internet Symposium on Food Allergens 2(Suppl.5):1-12 (2000) [http://www.food-allergens.de]

6.2 Properties of alpha-Livetin (Chicken Serum Albumin)

6.2.1 Molecular Biological Properties
 
alpha-Livetin References
Allergen Nomenclature Gal d 5 (1) Larsen & Lowenstein 2000
Molecular Mass  70 kDa (1, 3), 66 kDa (2) (SDS-PAGE: 2, 3) (1) Williams et al. 1962
(2) de Blay et al. 1994
(3) Szepfalusi et al. 1994
Isoelectric Point pI 4.3 - 5.7 (1: livetins), pI 4.6-4.8 (2: serum albumin)
(1) Ternes 1989
(2) Miller & Gmeiner 1993
Amino Acid Sequence,mRNA, and cDNA
Protein Serum albumin
SWISS-PROT: P19121
GenBank: X60688, V00381
Amino Acids N-terminus: DAHK (1* ) 592 aa
mRNA precursor 1892 bp
cDNA precursor 571 bp (fragment, 3)
 *conflict to SWISS-PROT
(1) Sorkina et al. 1976
(2) Gordon et al. 1978
(3) Hache et al. 1983
Posttranslational Modifications
Disulfide bonds
17 disulfide bonds  (1)
(1) SWISS-PROT
Biological Function
Serum albumin: binding of water and Ca-, Na-, and K- cations, fatty acids, hormones, bilirubin and drugs; regulation of the colloidal osmotic blood pressure (1)
3 homologous domains:
domain I: 8-183
domain II: 202-375
domain III: 394-573
(1) SWISS-PROT
 * alpha-livetin and chicken serum albumin are identical (Williams et al. 1962)

 6.2.2 Allergenic Properties
 
alpha-Livetin References
Frequency of Sensitization
IgE-binding to alpha-livetin in 100% of patients  with bird feather and egg yolk allergy (1)
(1) see 6.1 Sensitization to Allergens of Bird's Egg Yolk and Feathers

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