6.2.1 Molecular Biological Properties
 

Chicken Serum Albumin	References
Allergen Nomenclature Gal d 5	(1) Allergen Nomenclature Sub-Committee 2001
Molecular Mass  70 kDa (1, 3), 66 kDa (2) (SDS-PAGE: 2, 3) Mr (calculated): 67.0 kDa (4)	(1) Williams et al. 1962 (2) de Blay et al. 1994 (3) Szepfalusi et al. 1994 (4) SWISS-PROT
Isoelectric Point pI 4.6-4.8 (serum albumin)	(1) Miller & Gmeiner 1993
Amino Acid Sequence,mRNA, and cDNA Protein Serum albumin SWISS-PROT: P19121 GenBank: X60688, V00381 PIR: S15571, ABCHS Amino Acids 592 aa (615 aa precursor) mRNA precursor 1892 bp cDNA precursor 571 bp (fragment, 2)  *conflict to SWISS-PROT	(1) Gordon et al. 1978 (2) Hache et al. 1983
Posttranslational Modifications Disulfide bonds 17 disulfide bonds  (1)	(1) SWISS-PROT
Biological Function Serum albumin: binding of water and Ca-, Na-, and K- cations, fatty acids, hormones, bilirubin and drugs; regulation of the colloidal osmotic blood pressure (1) 3 homologous domains: domain I: 8-183 (precursor 31-206) domain II: 202-375 (precursor 225-398) domain III: 394-573 (precursor 417-596)	(1) SWISS-PROT
Sequence Homology bovine serum albumin: aa sequence identity 45% (1)	(1) SWISS-PROT

 * chicken serum albumin and alpha-livetin are identical (Williams et al. 1962)

 6.2.2 Allergenic Properties
 

Chicken Serum Albumin	References
Frequency of Sensitization IgE-binding to chicken serum albumin in 100% of patients with bird-egg syndrome (1)	(1) see 6.1 Sensitization to Allergens of Chicken Meat
Stability of Chicken Serum Albumin	(1) see 9 Stability of Chicken Meat Allergens