6.8.1 Molecular Biological Properties
| Kunitz-trypsin Inhibitor (KTI) | References | ||||||||||||||||||||||||||||
| Allergen Nomenclature none | |||||||||||||||||||||||||||||
| Molecular Mass 20 kDa | (1) Baur et al. 1996 | ||||||||||||||||||||||||||||
|
Isoelectric
Point pI ~4.5
|
(1) Baur et al. 1996 | ||||||||||||||||||||||||||||
Amino Acid Sequence,
mRNA, and cDNA
|
(1) Kim et al. 1985
(2) Jofuku et al. 1989 |
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| recombinant Protein
Expression in tabacco plants: all 3 variants (1) |
(1) Jofuku & Goldberg 1989 | ||||||||||||||||||||||||||||
| 3D-Structure
X-ray studies of complex with trypsin (1, 2) |
(1) Sweet et al. 1974
(2) Song & Suh 1998 |
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| Posttranslational Modifications
Disulfide bonds 2 disulfide bonds: 39-86, 136-145 (1) |
(1) Brown et al. 1966 | ||||||||||||||||||||||||||||
| Genetic Variants
3 variants (1) |
(1) Kim et al. 1985 | ||||||||||||||||||||||||||||
| Biological Function
inhibition of trypsin active site: Arg-63 (KTI A) (1) |
(1) Ozawa & Laskowski 1966 | ||||||||||||||||||||||||||||
| Sequence Homology
Lol p 11, a rye grass pollen allergen: 32% homology (1) |
(1) van Ree et al. 1995 |
6.8.2 Allergenic Properties
| Kunitz-trypsin Inhibitor (KTI) | References |
| Frequency of Sensitization
IgE-binding to Kunitz-trypsin inhibitor in 86% of patients (1) |
(1) see 6.1 Sensitization to Soybean Allergens |